Preheat oven to 400 degrees F; line a baking sheet with parchment paper and set aside.
Slice a "pocket" into the side of each chicken breast and spread 1 ounce of cream cheese inside each chicken breast. Sprinkle half of the flour over the tops of the chicken, spread with hands to cover surface. Flip chicken breast to the other side and repeat with remaining flour.
In one shallow dish, beat the egg with the water and set aside. In a second shallow dish, combine the sesame seeds, poppy seeds, minced onion, sea salt, and garlic powder; mix well.
Working one at a time, dip each chicken breast in the egg and then the seeds mixture to coat on all sides. Repeat with second chicken breast.
In a small skillet, heat the oil over medium-high heat. Once hot, add the prepared chicken breasts and cook 3-4 minutes per side or until golden; transfer to the prepared baking sheet.
Bake chicken for 25-30 minutes or until chicken is fully cooked through.